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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Fig. 2

Immunohistochemical analysis of LV-αsyn in α-syn KO, non-tg, and α-syn tg mice. α-syn KO, non-tg and α-syn tg mice were evaluated 16 weeks after unilateral LV injection into the hippocampus. Total α-syn antibody was used for these experiments. a Representative low and (b) high magnification of LV-control injected ipsi-laterally in α-syn KO mice revealed complete absence of any α-syn immunoreactivity in the hippocampus. c Representative low magnification and (d) high magnification of α-syn immunoreactivity in the ipsi-lateral and contra-lateral sides following LV-control injection in non-tg mice. e Representative low and (f) high magnification of α-syn immunoreactivity in the ipsi-lateral and contra-lateral sides following LV-control injection in α-syn tg mice. g Representative low magnification and (h) high magnification of α-syn immunoreactivity in the ipsi-lateral and contra-lateral sides following unilateral LV-α-syn injection in α-syn KO mice. i Representative low magnification and (j) high magnification of α-syn immunoreactivity in the ipsi-lateral and contra-lateral sides following LV-α-syn injection in non-tg mice. k Representative low and (l) high magnification of α-syn immunoreactivity in the ipsi-lateral and contra-lateral sides following LV-α-syn injection in α-syn tg mice. Low magnification scale bar = 250 μm; high magnification scale bar = 25 μm. N = 5 per group

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