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Fig. 11 | Acta Neuropathologica Communications

Fig. 11

From: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Fig. 11

Passive immunization with CT-α-syn antibodies improved behavioral deficits in α-syn KO and α-syn tg mice. The effect of immunization with CT-α syn antibodies on learning as well as memory and motor performance were analyzed by water maze. a Performance in the water maze (distance to the platform) during the cued with submerged platform tests in mice immunized with 27-1 (control), or with 1H7 (antibody). b Probe test performance, measured as the time spent in correct quadrant by mice passively immunized with either 27-1 or 1H7 antibodies. Error bars represent ± SEM. *P < 0.05 when comparing 27-1-immunized mice to 1H7-immunized mice within genotype. α-Syn KO mice + 27-1 (control) n = 8; α-syn KO + 1H7 antibody n = 9; non-tg mice + 27-1 (control) n = 10; non-tg mice + 1H7 antibody n = 9; α-syn tg mice + 27-1 (control) n = 8; α-syn tg mice + 1H7 antibody n = 8

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