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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

Fig. 1

Schematic overview of the experimental paradigm. a Study Design. α-Syn KO, non-tg, and α-syn tg mice were injected with LV-α-syn 1 week before beginning passive immunization with systemic (intraperitoneal) injections of either control IgG (27-1) or α-syn 91-99 antibody (1H7). Immunization occurred once a week for a total of 13 weeks. Water maze testing occurred 14 weeks after LV-α-syn injection. Mice were euthanized 16 weeks after LV-α-syn injection. b Schematic representation of the unilateral injection of LV-α-syn into the hippocampus. c Schematic representation of the α-syn molecule and the binding epitope of the 1H7 antibody. Area in red represents the central hydrophobic region [23, 24, 70]

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