Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

Fig. 1

Combined treatment reduces astrogliosis and microgliosis in MBP-α-syn transgenic mice. a-c Representative images of GFAP immunostaining and optical density quantification in neocortex (a), corpus callosum (b) and striatum (c) of non-tg and MBP-α-syn tg mice treated with LV-control or LV-CD5-D5-ApoB, and vehicle or lenalidomide. d-f Representative images of Iba1 immunostaining and optical density quantification in neocortex (d), corpus callosum (e) and striatum (f) of non-tg and MBP-α-syn tg mice treated with LV-control or LV-CD5-D5-ApoB, and vehicle or lenalidomide. Results are presented as average ± SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 when comparing vehicle/LV-control-treated non-tg mice to vehicle/LV-control-treated tg mice. # p < 0.05, ## p < 0.01 and ### p < 0.001 when comparing vehicle/LV-control-treated tg mice to single or multi-treated tg mice. Scale bar = 25 μm

Back to article page