Fig. 7

Correlation analysis of p-α-syn positive aggregates and gene expression profiles. Correlation analysis of p-α-syn positive aggregates (total number, total area, number of small, medium and large sized aggregates) and gene expression data identified a negative correlation between small sized p-α-syn positive aggregates and gene expression levels of the muscarinic acetylcholine receptor M3 (M3R), with a Spearman correlation coefficient of −0.72 and adjusted p-value of < 0.0001. Black filled circles showed data points of the PD group; white circles showed data points of the control group