Fig. 5

Distribution of p-α-syn positive aggregates according to size. Whereas for medium sized p-α-syn positive aggregates no significant differences were found between patients with PD (n = 12) and controls (n = 10) (b), patients with PD showed increased numbers of both small sized (a) and large sized (c) p-α-syn positive aggregates compared to controls. d Total number of p-α-syn positive aggregates per neuron was higher in patients with PD compared to controls due to the high amount of small sized p-α-syn positive aggregates. The relative portion of small (S) sized p-α-syn aggregates was higher in patients with PD, while the relative portion of medium (M) and large (L) sized p-α-syn aggregates were higher in controls (d). Data are presented as mean ± SEM; *p < 0.05 vs control; ***, p < 0.001