Fig. 4

Number and area of p-α-syn positive aggregates. The total number of p-α-syn positive aggregates per neuron (a) and the area of p- α -syn positive aggregates per neuron (b) are significantly increased in patients with PD (n = 12) compared to controls (n = 10). The percentage of p-α-syn positive aggregates per neuron was significant increased in patients with PD (c) as was the total number of p-α-syn positive aggregates normalized to the neuronal area (d). Data are presented as mean ± SEM; *p < 0.05 vs control; ***, p < 0.001 vs control