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Table 5 Tauopathies pathology

From: Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

Stain Frontal Cingulate Hippocampus Dentate Entorhinal Amygdala BG SN
Neuronal
 pThr175 ± − ++ (10/27) ± − ++ (10/25) ± − +++ (20/26) ± − ++ (8/28) ± − +++ (21/28) ± − +++ (19/23) ± − + (10/29) ± (3/23)
 PHF ± − ++++ (13/27) ± − +++ (16/24) ± − ++++ (28/29) ± − ++++ (18/29) ± − ++++ (28/29) ± − ++++ (21/21) ± − ++ (13/28) ± − ++ (7/23)
 pSer208,210 ± − +++ (12/27) ± − +++ (12/25) ± − +++ (25/29) ± − ++ (10/28) ± − +++ (23/28) ± − +++ (23/28) ± − ++ (9/28) ± − + (5/23)
 pThr217 ± − +++ (15/27) ± − +++ (14/24) ± − +++ (23/29) ± − ++ (12/29) ± − +++ (24/29) ± − +++ (19/21) ± − + (6/27) ± (7/23)
Glial
 pThr175 ± − +++ (6/27) ± − ++ (6/25) ± − + (4/29) ± (1/28) ± (2/28) ± − ++ (3/24) ± − ++ (16/29) ± (3/23)
 PHF ± − ++++ (8/27) ± − +++ (7/24) ± − + (5/29) - (0/29) ± − +++ (8/29) ± − +++ (12/21) ± − ++++ (11/28) - (0/23)
 pSer208,210 + − ++ (2/28) ± − +++ (3/25) ++ (3/29) ++ (1/28) ± − ++ (3/27) ± − +++ (3/22) ± − ++ (10/28) - (0/23)
 pThr217 ± − +++ (7/26) ± − +++ (7/24) ± − +++ (3/29) - (0/29) ++ − +++ (2/29) ± − +++ (4/21) ± − +++ (15/27) - (0/23)
Neuritic
 pThr175 ± − ++ (10/27) ± − ++ (9/25) ± − +++ (20/28) ± − ++ (6/28) ± − +++ (21/28) ± − +++ (16/24) ± − + (12/28) ± − ++ (10/23)
 PHF ± − ++++ (14/27) ± − ++++ (15/24) ± − ++++ (24/29) ± − + (11/29) ± − ++++ (28/29) ± − ++++ (17/21) ± − +++ (16/28) ± − ++++ (13/23)
 pSer208,210 ± − ++++ (18/27) ± − +++ (9/25) ± − ++
(18/29)
± − + (6/28) ± − +++ (22/28) ± − +++ (18/23) ± − ++ (11/28) ± − ++ (11/23)
 pThr217 ± − ++++ (15/27) ± − ++++ (14/25) ± − ++ (21/29) ± − + (11/29) ± − +++ (24/29) ± − ++++ (18/23) ± − +++ (11/27) ± − ++ (11/23)