Skip to main content

Table 4 ALSci pathology

From: Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

Stain Frontal Cingulate Hippocampus Dentate Entorhinal Amygdala BG SN
Neuronal
 pThr175 ± (4/5) ± (2/5) ± (5/5) + (1/5) + (4/4) + (1/1) - (0/5) - (0/3)
 PHF + (2/4) ± (3/3) ± − + (4/4) ± − + (2/4) ± − ++ (4/4) ± − ++ (2/2) - (0/5) ± (2/2)
 pSer208,210 ± (2/5) ± (3/5) ± − ++ (4/5) ± (1/5) ± − ++ (3/4) + (1/1) - (0/5) - (0/3)
 pThr217 ± (5/5) ± − + (3/5) ± − ++ (5/5) ± − ++ (3/5) ± − ++ (5/5) + (1/1) - (0/5) ± − + (2/2)
Glial
 pThr175 ± − ++ (2/5) ± − ++ (2/5) - (0/5) - (0/5) ± (1/4) - (0/1) ± − + (2/5) - (0/3)
 PHF ± − ++ (4/4) ± − ++ (2/3) - (0/4) - (0/4) - (0/4) + (1/2) ± (3/5) - (0/2)
 pSer208,210 ++ (4/5) ++ (2/5) - (0/5) - (0/5) ± (1/4) - (0/1) ± − + (4/5) ± (1/3)
 pThr217 ++ − +++ (5/5) +++ (2/5) ++ (2/5) - (0/5) ± (1/5) - (0/1) + − ++ (5/5) - (0/2)
Neuritic
 pThr175 ± − + (3/5) ± − + (2/5) ± − + (3/5) ± − ++ (4/5) ± − ++ (4/4) - (0/1) ± (4/5) ± (1/3)
 PHF ± − + (2/4) ± − + (3/3) ± − + (3/4) ± (3/4) ± − ++ (4/4) ± − ++ (2/2) ± (2/5) ± (2/2)
 pSer208,210 ± − + (2/5) ± (3/5) ± (4/5) ± (2/5) ± − ++ (4/5) + (1/1) ± (1/5) ± (1/3)
 pThr217 ± − ++ (5/5) ± − ++ (2/5) ± − + (4/5) ++ (2/5) + − +++ (5/5) + (1/1) ± (3/5) ± − ++ (2/2)