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Table 3 ALS pathology

From: Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

Stain Frontal Cingulate Hippocampus Dentate Entorhinal Amygdala BG SN
Neuronal
 pThr175 ± (1/5) ± (1/4) ± (1/5) ± (1/5) ± (2/4) ++ (1/2) - (0/5) - (0/5)
 PHF ± (1/5) ± (1/4) ± (3/5) ± (2/5) ± − ++ (5/5) +++ (1/1) ± (1/4) ± (3/4)
 pSer208,210 - (0/5) ++ (1/4) ± (1/5) - (0/4) ± (1/2) ++ (1/2) - (0/5) - (0/5)
 pThr217 + (1/5) ± (1/4) ± (1/5) - (0/4) ± − ++ (3/4) ++ (1/2) ± (1/4) ± (2/5)
Glial
 pThr175 ++ (1/5) - (0/5) - (0/4) - (0/5) - (0/2) ± (1/2) + (1/5) - (0/5)
 PHF ± (1/5) ± (1/4) ± (1/5) - (0/5) + (1/5) ++ (1/1) - (0/4) - (0/4)
 pSer208,210 - (0/5) - (0/4) - (0/5) - (0/4) ± (1/2) ++ (1/2) ++ (2/5) - (0/5)
 pThr217 +++ (1/5) +++ (1/4) + (1/5) - (0/4) +++ (1/4) ++ (1/2) ++ (2/4) - (0/5)
Neuritic
 pThr175 - (0/5) - (0/5) ± (1/4) - (0/4) ± (2/5) ++ (1/2) - (0/5) ± (1/5)
 PHF ± (2/5) ± (1/4) ± (3/5) - (0/5) + − ++ (5/5) ++ (1/1) ± (1/4) ± (3/4)
 pSer208,210 - (0/5) ± (1/4) - (0/5) - (0/4) ± (1/2) - (0/2) + (1/5) + (2/5)
 pThr217 ± (1/5) - (0/4) ± (1/5) - (0/4) ± − ++ (3/4) ± (1/2) + − ++ (2/4) + − ++ (3/5)