Table 3 ALS pathology
Stain | Frontal | Cingulate | Hippocampus | Dentate | Entorhinal | Amygdala | BG | SN |
|---|---|---|---|---|---|---|---|---|
Neuronal | ||||||||
pThr175 | ± (1/5) | ± (1/4) | ± (1/5) | ± (1/5) | ± (2/4) | ++ (1/2) | - (0/5) | - (0/5) |
PHF | ± (1/5) | ± (1/4) | ± (3/5) | ± (2/5) | ± − ++ (5/5) | +++ (1/1) | ± (1/4) | ± (3/4) |
pSer208,210 | - (0/5) | ++ (1/4) | ± (1/5) | - (0/4) | ± (1/2) | ++ (1/2) | - (0/5) | - (0/5) |
pThr217 | + (1/5) | ± (1/4) | ± (1/5) | - (0/4) | ± − ++ (3/4) | ++ (1/2) | ± (1/4) | ± (2/5) |
Glial | ||||||||
pThr175 | ++ (1/5) | - (0/5) | - (0/4) | - (0/5) | - (0/2) | ± (1/2) | + (1/5) | - (0/5) |
PHF | ± (1/5) | ± (1/4) | ± (1/5) | - (0/5) | + (1/5) | ++ (1/1) | - (0/4) | - (0/4) |
pSer208,210 | - (0/5) | - (0/4) | - (0/5) | - (0/4) | ± (1/2) | ++ (1/2) | ++ (2/5) | - (0/5) |
pThr217 | +++ (1/5) | +++ (1/4) | + (1/5) | - (0/4) | +++ (1/4) | ++ (1/2) | ++ (2/4) | - (0/5) |
Neuritic | ||||||||
pThr175 | - (0/5) | - (0/5) | ± (1/4) | - (0/4) | ± (2/5) | ++ (1/2) | - (0/5) | ± (1/5) |
PHF | ± (2/5) | ± (1/4) | ± (3/5) | - (0/5) | + − ++ (5/5) | ++ (1/1) | ± (1/4) | ± (3/4) |
pSer208,210 | - (0/5) | ± (1/4) | - (0/5) | - (0/4) | ± (1/2) | - (0/2) | + (1/5) | + (2/5) |
pThr217 | ± (1/5) | - (0/4) | ± (1/5) | - (0/4) | ± − ++ (3/4) | ± (1/2) | + − ++ (2/4) | + − ++ (3/5) |