Fig. 4
From: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
The relative mtDNA copy number in each disease cohort. a Top – Relative copy number of each cohort calculated as the ratio between the mean mtDNA read depth and the mean exome read depth as previously described [5]. ** (P < 0.01). b Bottom - The association between relative mtDNA copy number and age for all CJD cases (n = 182) with the Spearman Rank ρ and p-value shown. Key – AD –Alzheimer’s disease, CJD – Creutzfeldt Jacob Disease, DLB-PD – Dementia with Lewy Bodies or Parkinson’s disease, FTD-ALS – Frontotemporal Dementia or Amyotrophic Lateral Sclerosis