Fig. 2
From: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
Circos plot summarizing all of the genetic data from 1363 sequences derived form the MRC Brain Tissue Resource. From outside the circle to inside: (1) mtDNA position, (2) mtDNA genes, (3) mtDNA Complex, (4) frequency of variants in 40,440 mitochondrial sequences in NCBI-GenBank, (5) mean read depth of 1363 samples per base, (6) Total variants in all 1363 samples [circles], (7) Total Rare variants in 1363 samples [triangles], (8) Total novel variants in 1363 samples [squares]. Colour code for circles (6) – (8): Red - AD, green - ALS-FTD, blue - CJD, yellow - DLB-PD, grey - others; from inner to outer, HF increasing. Key – AD –Alzheimer’s disease, CJD – Creutzfeldt Jacob Disease, DLB-PD – Dementia with Lewy Bodies or Parkinson’s disease, FTD-ALS – Frontotemporal Dementia or Amyotrophic Lateral Sclerosis