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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

Fig. 2

ENSA does not interfere with aSyn fibrillization. The formation of amyloid-like fibrils was monitored in a solution of A30P (a) or G51D (b) (40 μM of each) with or without ENSA (10–40 μM), or in a solution of ENSA alone (10–40 μM) (c). The protein solutions were incubated at 37 °C with constant agitation and analyzed at various times for thioflavin T fluorescence. The graphs show the mean fluorescence normalized to the maximal signal at the end of the incubation (a, b) or the mean, unnormalized fluorescence (c) plotted against the incubation time. The dotted lines above and below each solid line in (a) and (b) correspond to the mean signal ± SEM; n = 3 (a), n = 4 (b), or n = 2 (c)

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