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Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

Acta Neuropathologica Communications volume 4, Article number: 129 (2016) Cite this article

The Original Article was published on 13 December 2014

Retraction note

The authors are retracting this article [1]. Careful re-examination of the transgenic mice used in this study has indicated that they contain a transgenic sequence containing a 90CGG repeat, associated with fragile X-associated tremor/ataxia syndrome (FXTAS). Apparently, a mixture of two constructs containing the G4C2 repeat and the CGG repeat sequence was injected in oocytes to generate transgenic mice. The presence of the CGG repeat can explain the neuropathology described in the mice used for this study. We are therefore unable to present this transgenic mouse as model for C9orf72 related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

References

  1. Hukema RK et al (2014) A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD. Acta Neuropathol Commun 2:166. doi:10.1186/s40478-014-0166-y

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    Authors and Affiliations

    1. Department of Clinical Genetics, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands

      Renate K. Hukema, Fréderike W. Riemslagh, Herma C. van der Linde, Lies-Anne W. F. M. Severijnen & Rob Willemsen

    2. Department of Neurology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands

      Fréderike W. Riemslagh, Shamiram Melhem & John C. van Swieten

    3. German Center for Neurodegenerative Diseases, 81337, Munich, Germany

      Dieter Edbauer

    4. Department of Cell Biology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands

      Alex Maas

    5. Department of Neurobiology and Genetics, IGBMC, INSERM U964, CNRS UMR7104, University of Strasbourg, Illkirch, France

      Nicolas Charlet-Berguerand

    6. Department of Neurology, Neuroscience Campus Amsterdam, 1007 MB, Amsterdam, The Netherlands

      John C. van Swieten

    7. PO Box 2040, 3000 CA, Rotterdam, The Netherlands

      Renate K. Hukema

    Authors
    1. Renate K. Hukema
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    2. Fréderike W. Riemslagh
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    3. Shamiram Melhem
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    4. Herma C. van der Linde
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    5. Lies-Anne W. F. M. Severijnen
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    6. Dieter Edbauer
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    8. Nicolas Charlet-Berguerand
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    9. Rob Willemsen
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    10. John C. van Swieten
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    Corresponding author

    Correspondence to Renate K. Hukema.

    Additional information

    The online version of the original article can be found under doi:10.1186/s40478-014-0166-y.

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    Hukema, R.K., Riemslagh, F.W., Melhem, S. et al. Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD. acta neuropathol commun 4, 129 (2016). https://doi.org/10.1186/s40478-016-0401-9

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    • DOI: https://doi.org/10.1186/s40478-016-0401-9

    Acta Neuropathologica Communications

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