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Table 3 Ridge regression coefficients of cognitive performance scores from AON and ERC pathologies

From: Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

  AON (n = 19) ERC (n = 18)
Predicting cognition Marker Coefficient p value Marker Coefficient p value
GCS Active Casp6 −0.18 0.01 Active Casp6 −0.02 0.40
TauΔCasp6 −0.08 0.29 TauΔCasp6 −0.05 0.06
PHF-1 −0.06 0.33 PHF-1 −0.03 0.27
−0.18 0.04 −0.03 0.27
MMSE Active Casp6 −1.97 0.001 Active Casp6 −0.29 0.23
TauΔCasp6 −1.36 0.05 TauΔCasp6 −0.72 0.01
PHF-1 −0.92 0.06 PHF-1 −0.41 0.04
−0.90 0.21 −0.30 0.14
Episodic Memory Active Casp6 −0.31 0.01 Active Casp6 −0.02 0.67
TauΔCasp6 −0.13 0.32 TauΔCasp6 −0.07 0.07
PHF-1 −0.14 0.17 PHF-1 −0.05 0.24
−0.28 0.05 −0.05 0.27
Working memory Active Casp6 −0.06 0.26 Active Casp6 −0.02 0.21
TauΔCasp6 −0.03 0.59 TauΔCasp6 −0.01 0.64
PHF-1 −0.004 0.93 PHF-1 −0.004 0.81
−0.09 0.16 0.001 0.95
Semantic memory Active Casp6 −0.15 0.03 Active Casp6 −0.01 0.69
TauΔCasp6 −0.11 0.14 TauΔCasp6 −0.05 0.05
PHF-1 −0.07 0.25 PHF-1 −0.02 0.55
−0.16 0.06 −0.03 0.28
VSA Active Casp6 −0.09 0.12 Active Casp6 −0.01 0.62
TauΔCasp6 −0.01 0.91 TauΔCasp6 −0.01 0.84
PHF-1 0.02 0.72 PHF-1 −0.01 0.57
−0.06 0.41 −0.03 0.21
PS Active Casp6 −0.08 0.23 Active Casp6 −0.05 0.05
TauΔCasp6 −0.07 0.32 TauΔCasp6 −0.05 0.04
PHF-1 −0.02 0.71 PHF-1 −0.02 0.29
−0.04 0.64 −0.02 0.31
  1. Data represent the ridge regression analysis of the different markers in the AON and the ERC and the cognitive scores. Model adjusted for sex, age, PMI and years of education, in bold p values less or equal to 0.05