Table 3 Ridge regression coefficients of cognitive performance scores from AON and ERC pathologies
|  | AON (n = 19) | ERC (n = 18) | ||||
|---|---|---|---|---|---|---|
Predicting cognition | Marker | Coefficient | p value | Marker | Coefficient | p value |
GCS | Active Casp6 | −0.18 | 0.01 | Active Casp6 | −0.02 | 0.40 |
TauΔCasp6 | −0.08 | 0.29 | TauΔCasp6 | −0.05 | 0.06 | |
PHF-1 | −0.06 | 0.33 | PHF-1 | −0.03 | 0.27 | |
Aβ | −0.18 | 0.04 | Aβ | −0.03 | 0.27 | |
MMSE | Active Casp6 | −1.97 | 0.001 | Active Casp6 | −0.29 | 0.23 |
TauΔCasp6 | −1.36 | 0.05 | TauΔCasp6 | −0.72 | 0.01 | |
PHF-1 | −0.92 | 0.06 | PHF-1 | −0.41 | 0.04 | |
Aβ | −0.90 | 0.21 | Aβ | −0.30 | 0.14 | |
Episodic Memory | Active Casp6 | −0.31 | 0.01 | Active Casp6 | −0.02 | 0.67 |
TauΔCasp6 | −0.13 | 0.32 | TauΔCasp6 | −0.07 | 0.07 | |
PHF-1 | −0.14 | 0.17 | PHF-1 | −0.05 | 0.24 | |
Aβ | −0.28 | 0.05 | Aβ | −0.05 | 0.27 | |
Working memory | Active Casp6 | −0.06 | 0.26 | Active Casp6 | −0.02 | 0.21 |
TauΔCasp6 | −0.03 | 0.59 | TauΔCasp6 | −0.01 | 0.64 | |
PHF-1 | −0.004 | 0.93 | PHF-1 | −0.004 | 0.81 | |
Aβ | −0.09 | 0.16 | Aβ | 0.001 | 0.95 | |
Semantic memory | Active Casp6 | −0.15 | 0.03 | Active Casp6 | −0.01 | 0.69 |
TauΔCasp6 | −0.11 | 0.14 | TauΔCasp6 | −0.05 | 0.05 | |
PHF-1 | −0.07 | 0.25 | PHF-1 | −0.02 | 0.55 | |
Aβ | −0.16 | 0.06 | Aβ | −0.03 | 0.28 | |
VSA | Active Casp6 | −0.09 | 0.12 | Active Casp6 | −0.01 | 0.62 |
TauΔCasp6 | −0.01 | 0.91 | TauΔCasp6 | −0.01 | 0.84 | |
PHF-1 | 0.02 | 0.72 | PHF-1 | −0.01 | 0.57 | |
Aβ | −0.06 | 0.41 | Aβ | −0.03 | 0.21 | |
PS | Active Casp6 | −0.08 | 0.23 | Active Casp6 | −0.05 | 0.05 |
TauΔCasp6 | −0.07 | 0.32 | TauΔCasp6 | −0.05 | 0.04 | |
PHF-1 | −0.02 | 0.71 | PHF-1 | −0.02 | 0.29 | |
Aβ | −0.04 | 0.64 | Aβ | −0.02 | 0.31 | |