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Table 2 AON and ERC immunostaining levels in NCI, MCI and AD

From: Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

Region of interest Clinical Diagnosis   Active Casp6 TauΔCasp6 PHF-1
AON NCI Median 837.7 472.9 3655.9 403.3
IQR 289.0–1481.8 263.0–4182.6 1248.2–23248.5 109.9–658.2
n 11 11 11 10
MCI Median 226.1 980.7 7494.4 452.9
IQR 118.1–2705.2 458.0–9493.4 651.1–67082.5 136.3–2993.1
n 6 6 7 7
AD Median 23982.4 20400.0 75146.7 27355.0
IQR 11445.0–26221.2 3087.2–54521.9 41473.2–151857.4 1222.9–55633.7
n 4 4 5 5
ERC NCI Median 69.7 29.3 4138.2 940.7
IQR 53.8–518.3 10.8–1138.3 615.9–16672.1 106.5–3406.6
n 8 9 9 9
MCI Median 662.4 1035.8 15562.1 96.1
IQR 14.4–1639.4 246.8–3901.1 9394.8–42729.6 54.2–4787.4
n 7 7 7 7
AD Median 1022.1 7859.5 56051.4 14342.6
IQR 497.2–1453.1 3181.4–18251.4 53590.7–70360.4 11159.6–24689.1
n 4 5 3 5
  1. Data represent the median (μm2 staining/μm2 tissue) and the Inter-Quartile Range (25% percentile-75% percentile). n indicates the number of cases studied with each immunostaining in this region of interest. Comparisons of distributions for pathological markers by clinical diagnosis were done separately in the AON and in the ERC using the Kruskal-Wallis test, followed by a Dunn’s post-hoc test where warranted (results and p values are reported in the text)