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Table 2 AON and ERC immunostaining levels in NCI, MCI and AD

From: Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

Region of interest

Clinical Diagnosis

 

Active Casp6

TauΔCasp6

PHF-1

AON

NCI

Median

837.7

472.9

3655.9

403.3

IQR

289.0–1481.8

263.0–4182.6

1248.2–23248.5

109.9–658.2

n

11

11

11

10

MCI

Median

226.1

980.7

7494.4

452.9

IQR

118.1–2705.2

458.0–9493.4

651.1–67082.5

136.3–2993.1

n

6

6

7

7

AD

Median

23982.4

20400.0

75146.7

27355.0

IQR

11445.0–26221.2

3087.2–54521.9

41473.2–151857.4

1222.9–55633.7

n

4

4

5

5

ERC

NCI

Median

69.7

29.3

4138.2

940.7

IQR

53.8–518.3

10.8–1138.3

615.9–16672.1

106.5–3406.6

n

8

9

9

9

MCI

Median

662.4

1035.8

15562.1

96.1

IQR

14.4–1639.4

246.8–3901.1

9394.8–42729.6

54.2–4787.4

n

7

7

7

7

AD

Median

1022.1

7859.5

56051.4

14342.6

IQR

497.2–1453.1

3181.4–18251.4

53590.7–70360.4

11159.6–24689.1

n

4

5

3

5

  1. Data represent the median (μm2 staining/μm2 tissue) and the Inter-Quartile Range (25% percentile-75% percentile). n indicates the number of cases studied with each immunostaining in this region of interest. Comparisons of distributions for pathological markers by clinical diagnosis were done separately in the AON and in the ERC using the Kruskal-Wallis test, followed by a Dunn’s post-hoc test where warranted (results and p values are reported in the text)