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Table 6 Frequency of regional β-amyloid abnormality

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

  Neocortical region
  CERAD regions     
  MFL STG MTG IPL ACG PCG PRC PVC
Pathology
 Frequency region maximala 13 (17%) 5 (7%) 33 (43%) 19 (25%) 8 (11%) 6 (8%) 12 (16%) 17 (22%)
 Frequency region abnormal mCERADSOT >1.5 (of 76 abnormal cases) 61 (80%) 57 (75%) 65 (85%) 66 (87%) 56 (74%) 63 (83%) 57 (75%) 60 (79%)
 PETb Frontalc Temporal Parietal   PCG/PRC  
 Frequency abnormal 5 reads per case (of 71 abnormal cases by majority) 326 (92%) 299 (84%) 323 (91%)   331 (93%)  
  1. MFL midfrontal lobe, STG superior temporal gyrus, MTG middle temporal gyrus, IPL inferior parietal lobe, ACG anterior cingulate gyrus, PCG posterior cingulate gyrus, PRC Precuneus, PVC primary visual cortex
  2. amultiple regions may be simultaneously the region of maximal involvement
  3. bBIE assessment also included the subcortical striatal region which was abnormal in 302 assessments (85%)
  4. cThe frontal lobe was also assessed with the anterior-most aspect of the anterior cingulate in BIE assessment