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Table 6 Frequency of regional β-amyloid abnormality

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

 

Neocortical region

 

CERAD regions

    
 

MFL

STG

MTG

IPL

ACG

PCG

PRC

PVC

Pathology

 Frequency region maximala

13 (17%)

5 (7%)

33 (43%)

19 (25%)

8 (11%)

6 (8%)

12 (16%)

17 (22%)

 Frequency region abnormal mCERADSOT >1.5 (of 76 abnormal cases)

61 (80%)

57 (75%)

65 (85%)

66 (87%)

56 (74%)

63 (83%)

57 (75%)

60 (79%)

 PETb

Frontalc

Temporal

Parietal

 

PCG/PRC

 

 Frequency abnormal 5 reads per case (of 71 abnormal cases by majority)

326 (92%)

299 (84%)

323 (91%)

 

331 (93%)

 
  1. MFL midfrontal lobe, STG superior temporal gyrus, MTG middle temporal gyrus, IPL inferior parietal lobe, ACG anterior cingulate gyrus, PCG posterior cingulate gyrus, PRC Precuneus, PVC primary visual cortex
  2. amultiple regions may be simultaneously the region of maximal involvement
  3. bBIE assessment also included the subcortical striatal region which was abnormal in 302 assessments (85%)
  4. cThe frontal lobe was also assessed with the anterior-most aspect of the anterior cingulate in BIE assessment