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Table 5 Summary statistics and case status for each of the β-amyloid dichotomy algorithms

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

  Case status (5 readers per case) Pathology   
Reference standard TN FP FN TP Normal Abnormal Sensitivitya Specificityb
mCERADSOT c 131 19 33 347 30 76 91% 87%
mCERADmode d 134 26 30 340 32 74 92% 84%
CERADe 134 51 30 315 37 69 91% 72%
Amyloid phasef 108 2 56 364 22 84 87% 98%
  1. TN true negative, FP false positive, FN false negative, TP true positive
  2. asensitivity (true positive rate) = TP/(TP + FN)
  3. bspecificity (true negative rate) = TN/(TN + FP)
  4. cAbnormal defined as any regional mCERADSOT score > 1.5). Note while these analyses are presented by individual reads, the a priori analysis was by majority read (sensitivity was 91% and specificity was 90% by majority read N = 106)
  5. dAbnormal defined as any CERAD region moderate or frequent (multiple measures)
  6. eAbnormal defined as and CERAD region moderate or frequent (single point estimate)
  7. fAbnormal defined as phase 3, 4 or 5