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Table 5 Summary statistics and case status for each of the β-amyloid dichotomy algorithms

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

 

Case status (5 readers per case)

Pathology

  

Reference standard

TN

FP

FN

TP

Normal

Abnormal

Sensitivitya

Specificityb

mCERADSOT c

131

19

33

347

30

76

91%

87%

mCERADmode d

134

26

30

340

32

74

92%

84%

CERADe

134

51

30

315

37

69

91%

72%

Amyloid phasef

108

2

56

364

22

84

87%

98%

  1. TN true negative, FP false positive, FN false negative, TP true positive
  2. asensitivity (true positive rate) = TP/(TP + FN)
  3. bspecificity (true negative rate) = TN/(TN + FP)
  4. cAbnormal defined as any regional mCERADSOT score > 1.5). Note while these analyses are presented by individual reads, the a priori analysis was by majority read (sensitivity was 91% and specificity was 90% by majority read N = 106)
  5. dAbnormal defined as any CERAD region moderate or frequent (multiple measures)
  6. eAbnormal defined as and CERAD region moderate or frequent (single point estimate)
  7. fAbnormal defined as phase 3, 4 or 5