From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection
Demographics | Neuropathology | Imaging | |||||||||||
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Case | Age | Sex | Timea | Dementiab | mCsc | Aβd | ADe | CERADf | Braakg | Amyloid phaseh | Diagnosesi | SUVRj | PETmajk |
1 | 73 | F | 360 | Yes | 0.0 | n.d. | Normal | - | II | 1 | Inf TDPl | 1.13 | Normal |
2 | 84 | M | 17 | Yes | 0.0 | 0.3 | Normal | - | I | 0 | Normal | 1.18 | Normal |
3 | 83 | M | 568 | No | 0.0 | n.d. | Normal | - | IV | 1 | LBD | 1.17 | Normal |
4 | 91 | M | 130 | Yes | 0.0 | 0.9 | Normal | - | 0 | 0 | PSP VAD | 1.34 | Normal |
5 | 63 | M | 433 | No | 0.0 | n.d. | Low | - | II | 1 | PSP | 1.42 | Normal |
6 | 76 | F | 145 | Yes | 0.0 | n.d. | Normal | - | II | 1 | LBD VAD | 1.22 | Normal |
7 | 70 | M | 16 | No | 0.0 | n.d. | Normal | - | 0 | 0 | Normal | 1.44 | Normal |
8 | 67 | M | 32 | No | 0.0 | n.d. | Normal | - | I | 0 | Normal | 1.37 | Normal |
9 | 80 | M | 131 | Yes | 0.0 | n.d. | NA | - | III | 0 | TPD | 1.26 | Normal |
10 | 61 | F | 34 | No | 0.0 | n.d. | Normal | - | 0 | 1 | Normal | 1.67 | Normal |
11 | 65 | F | 393 | No | 0.0 | n.d. | Normal | - | III | 1 | AC | 1.21 | Normal |
12 | 60 | M | 374 | No | 0.0 | n.d. | Low | - | III | 1 | VAD | 1.34 | Normal |
13 | 74 | M | 170 | Yes | 0.1 | 8.1 | Normal | - | 0 | 2 | VAD | 1.12 | Normal |
14 | 66 | M | 155 | No | 0.1 | n.d. | Normal | - | 0 | 0 | AC | 1.3 | Normal |
15 | 76 | F | 10 | Yes | 0.1 | 0.2 | Normal | - | I | 2 | Normal | 1.56 | Normal |
16 | 63 | M | 12 | No | 0.1 | n.d. | Normal | - | 0 | 0 | Normal | 1.6 | Normal |
17 | 73 | F | 105 | Yes | 0.5 | 0.4 | Normal | - | V | 1 | TPD | 1.34 | Normal |
18 | 90 | F | 115 | Yes | 0.0 | n.d. | Low | S | III | 1 | Inf AS | 1.4 | Normal |
19 | 89 | F | 78 | No | 0.3 | n.d. | Int | S | IV | 2 | CAA AD | 1.25 | Normal |
20 | 82 | F | 24 | Yes | 0.4 | 0 | Low | S | III | 1 | LBD | 1.72 | Normal |
21 | 92 | F | 210 | Yes | 0.7 | n.d. | Normal | S | II | 4 | CAA PD | 1.55 | Normal |
22 | 84 | F | 69 | Yes | 1.1 | 1 | Int | S | II | 2 | Inf | 1.36 | Normal |
23 | 72 | M | 142 | Yes | 1.3 | n.d. | Normal | S | 0 | 3 | FTD | 1.01 | Normal |
24 | 87 | F | 76 | Yes | 1.4 | 2 | Low | S | I | 3 | VAD | 1.57 | Normal |
25 | 87 | F | 137 | Yes | 1.5 | n.d. | Normal | S | 0 | 2 | AC AS | 1.53 | Normal |
26 | 60 | M | 11 | Yes | 1.7 | n.d. | Low | S | II | 4 | CAA | 1.08 | Normal |
27 | 81 | M | 189 | No | 1.8 | n.d. | Normal | S | I | 4 | ND | 1.6 | Normal |
28 | 92 | F | 212 | Yes | 2.1 | n.d. | Int | S | III | 3 | TDPl | 1.26 | Normal |
29 | 87 | F | 131 | Yes | 1.4 | 8.1 | Low | S | IV | 5 | LBD | 1.95 | Abnormal |
30 | 96 | F | 630 | Yes | 1.9 | n.d. | High | S | VI | 5 | AD | 2.15 | Abnormal |
31 | 92 | F | 132 | Yes | 1.9 | n.d. | Low | S | III | 4 | LBD | 2.72 | Abnormal |
32 | 89 | F | 311 | Yes | 2.0 | n.d. | Int | S | III | 5 | AD CAA VAD | 2.33 | Abnormal |
33 | 88 | F | 118 | Yes | 2.1 | n.d. | Low | S | II | 4 | Inf LBD AS | 3.14 | Abnormal |
34 | 80 | M | 2 | Yes | 2.1 | 7.6 | High | S | VI | 5 | AD LBD | 2.1 | Abnormal |
35 | 94 | F | 19 | Yes | 2.1 | 7.7 | Int | S | III | 5 | AD | 1.95 | Abnormal |
36 | 88 | F | 329 | Yes | 2.1 | n.d. | High | S | V | 5 | AD | 2.84 | Abnormal |
37 | 74 | F | 550 | Yes | 2.8 | n.d. | High | S | VI | 5 | AD | 2.23 | Abnormal |
38 | 86 | M | 19 | No | 1.4 | 2.3 | Int | M | III | 3 | AD | 1.45 | Normal |
39 | 75 | M | 64 | Yes | 1.4 | 1.4 | Int | M | II | 3 | Inf LBD | 1.23 | Normal |
40 | 84 | M | 349 | Yes | 1.6 | n.d. | Int | M | V | 3 | AD LBD AS VAD Ath | 1.73 | Normal |
41 | 93 | M | 323 | No | 1.9 | n.d. | Low | M | II | 3 | LBD | 1.36 | Normal |
42 | 87 | M | 22 | No | 2.7 | 4 | Int | M | IV | 4 | AD | 2.04 | Normal |
43 | 86 | F | 193 | Yes | 0.3 | 9.4 | Low | M | III | 4 | LBD | 2.07 | Abnormal |
44 | 76 | M | 84 | Yes | 1.5 | 10.3 | Low | M | II | 3 | LBD | 1.87 | Abnormal |
45 | 75 | M | 373 | Yes | 1.6 | n.d. | Int | M | IV | 5 | AD CAA | 1.48 | Abnormal |
46 | 82 | F | 127 | Yes | 1.7 | n.d. | Int | M | IV | 4 | AD LBD | 2.32 | Abnormal |
47 | 86 | M | 395 | Yes | 1.8 | n.d. | High | M | V | 5 | AD | 2.83 | Abnormal |
48 | 93 | F | 500 | Yes | 1.8 | n.d. | Int | M | V | 3 | AD AS VAD | 1.6 | Abnormal |
49 | 84 | M | 45 | Yes | 1.8 | n.d. | Low | M | II | 3 | VAD | 1.85 | Abnormal |
50 | 93 | F | 243 | Yes | 1.9 | n.d. | High | M | VI | 5 | AD | 2.72 | Abnormal |
51 | 93 | F | 755 | Yes | 2.0 | n.d. | High | M | IV | 5 | AD | 2.2 | Abnormal |
52 | 80 | M | 276 | Yes | 2.0 | n.d. | High | M | VI | 4 | AD | 2.33 | Abnormal |
53 | 90 | M | 308 | Yes | 2.1 | n.d. | Low | M | II | 4 | LBD | 2.19 | Abnormal |
54 | 78 | M | 62 | Yes | 2.1 | 10.1 | High | M | VI | 5 | AD LBD | 2.86 | Abnormal |
55 | 86 | F | 747 | Yes | 2.1 | n.d. | Int | M | IV | 3 | AD CAA | 1.81 | Abnormal |
56 | 73 | F | 295 | No | 2.2 | n.d. | Low | M | I | 3 | LBD | 1.76 | Abnormal |
57 | 87 | F | 318 | Yes | 2.2 | n.d. | Int | M | III | 5 | AD AS VAD Ath | 2.26 | Abnormal |
58 | 88 | F | 266 | Yes | 2.2 | n.d. | Int | M | III | 4 | AD LBD | 1.91 | Abnormal |
59 | 88 | F | 79 | Yes | 2.3 | 17.6 | High | M | VI | 5 | AD | 1.67 | Abnormal |
60 | 93 | F | 396 | Yes | 2.3 | n.d. | High | M | VI | 5 | AD CAA Inf | 3.08 | Abnormal |
61 | 85 | M | 60 | No | 2.4 | 14.7 | High | M | VI | 5 | CAA AD VAD | 2.81 | Abnormal |
62 | 91 | M | 30 | Yes | 2.4 | 2.9 | High | M | V | 4 | AD | 1.86 | Abnormal |
63 | 95 | F | 15 | Yes | 2.4 | 7.5 | High | M | VI | 5 | AD | 1.89 | Abnormal |
64 | 79 | M | 42 | No | 2.4 | n.d. | Int | M | III | 4 | CAA mCa AD | 2.44 | Abnormal |
65 | 81 | F | 184 | Yes | 2.5 | n.d. | Int | M | IV | 3 | LBD | 1.66 | Abnormal |
66 | 84 | F | 193 | Yes | 2.6 | n.d. | High | M | V | 5 | AD | 2.4 | Abnormal |
67 | 72 | M | 268 | Yes | 2.7 | n.d. | High | M | VI | 5 | AD VAD | 2.07 | Abnormal |
68 | 63 | M | 342 | Yes | 2.8 | n.d. | High | M | VI | 5 | AD AS VAD | 1.94 | Abnormal |
69 | 89 | F | 115 | Yes | 3.0 | n.d. | High | M | VI | 5 | AD CAA LBD AS | 2.39 | Abnormal |
70 | 83 | F | 611 | Yes | 1.8 | n.d. | Low | F | I | 4 | AS CAA VAD TDPl | 1.87 | Normal |
71 | 84 | F | 189 | No | 1.7 | n.d. | Int | F | 0 | 3 | CAA Inf VAD AD | 2.02 | Abnormal |
72 | 82 | M | 397 | Yes | 1.9 | n.d. | High | F | VI | 5 | AD CAA VAD | 2.41 | Abnormal |
73 | 86 | F | 155 | Yes | 2.0 | n.d. | High | F | V | 5 | AD | 2.43 | Abnormal |
74 | 93 | F | 594 | Yes | 2.0 | n.d. | High | F | IV | 5 | AD | 2.46 | Abnormal |
75 | 90 | F | 538 | Yes | 2.0 | n.d. | High | F | VI | 4 | AD CAA AS VAD | 2.78 | Abnormal |
76 | 78 | F | 180 | Yes | 2.2 | n.d. | Normal | F | 0 | 4 | MSA | 2.03 | Abnormal |
77 | 93 | F | 200 | Yes | 2.2 | n.d. | High | F | V | 5 | AD AS CAA LBD VAD | 2.42 | Abnormal |
78 | 78 | F | 125 | Yes | 2.2 | n.d. | High | F | VI | 5 | AD LBD | 2.12 | Abnormal |
79 | 72 | M | 1 | Yes | 2.4 | 11.4 | High | F | VI | 5 | AD | 2.37 | Abnormal |
80 | 76 | F | 27 | Yes | 2.4 | n.d. | High | F | VI | 5 | AD CAA | 1.83 | Abnormal |
81 | 77 | F | 11 | Yes | 2.4 | 8.9 | High | F | VI | 4 | AD | 1.59 | Abnormal |
82 | 91 | F | 55 | Yes | 2.4 | 11.2 | High | F | VI | 4 | AD CAA | 2.2 | Abnormal |
83 | 81 | M | 204 | Yes | 2.4 | n.d. | High | F | VI | 4 | AD CAA LBD | 2.41 | Abnormal |
84 | 82 | M | 15 | Yes | 2.5 | 6.9 | High | F | VI | 4 | AD CAA | 2.23 | Abnormal |
85 | 83 | M | 34 | Yes | 2.5 | 8.5 | High | F | VI | 5 | AD | 2.6 | Abnormal |
86 | 90 | F | 51 | Yes | 2.5 | 12.2 | High | F | VI | 4 | AD | 2.35 | Abnormal |
87 | 73 | F | 27 | Yes | 2.5 | 9.6 | High | F | VI | 5 | AD | 2.23 | Abnormal |
88 | 87 | M | 1 | Yes | 2.5 | 7.8 | High | F | IV | 4 | AD CAA | 2.1 | Abnormal |
89 | 89 | F | 768 | Yes | 2.5 | n.d. | High | F | V | 5 | AD CAA LBD AS | 1.93 | Abnormal |
90 | 79 | M | 332 | Yes | 2.5 | n.d. | High | F | VI | 5 | AD CAA LBD | 2.24 | Abnormal |
91 | 80 | M | 0 | Yes | 2.6 | 7.9 | High | F | VI | 5 | AD | 2 | Abnormal |
92 | 79 | F | 422 | Yes | 2.6 | n.d. | High | F | V | 5 | AD CAA LBD AS VAD HC | 2.38 | Abnormal |
93 | 87 | M | 106 | Yes | 2.6 | n.d. | High | F | VI | 5 | AD | 2.2 | Abnormal |
94 | 66 | F | 139 | Yes | 2.7 | n.d. | High | F | VI | 5 | AD | 2.37 | Abnormal |
95 | 84 | M | 181 | Yes | 2.7 | n.d. | High | F | V | 4 | AD LBD | 2.75 | Abnormal |
96 | 87 | M | 769 | Yes | 2.7 | n.d. | High | F | VI | 5 | AD CAA LBD VAD | 2.5 | Abnormal |
97 | 71 | M | 305 | Yes | 2.7 | n.d. | High | F | V | 5 | AD CAA | 2.47 | Abnormal |
98 | 72 | F | 565 | Yes | 2.7 | n.d. | High | F | VI | 5 | AD CAA LBD | 2.58 | Abnormal |
99 | 85 | M | 846 | Yes | 2.8 | n.d. | High | F | VI | 5 | AD VAD | 2.01 | Abnormal |
100 | 84 | F | 198 | Yes | 2.8 | 6.3 | High | F | VI | 4 | AD | 1.48 | Abnormal |
101 | 85 | F | 436 | Yes | 2.9 | n.d. | High | F | VI | 5 | AD | 2.65 | Abnormal |
102 | 75 | F | 66 | Yes | 2.9 | 10.6 | High | F | VI | 5 | AD | 2.47 | Abnormal |
103 | 87 | M | 493 | No | 2.9 | n.d. | High | F | IV | 5 | CAA LBD AD | 2.42 | Abnormal |
104 | 86 | F | 127 | Yes | 3.0 | n.d. | High | F | VI | 5 | AD | 2.9 | Abnormal |
105 | 81 | M | 171 | Yes | 3.0 | n.d. | High | F | VI | 5 | AD | 2.34 | Abnormal |
106 | 63 | M | 562 | Yes | 3.0 | n.d. | High | F | VI | 5 | AD | 2.72 | Abnormal |