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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

Fig. 6

Neocortical diffuse and neuritic plaque frequency and probability of PET positive interpretation increases with β-amyloid phase. Amyloid phase represents a progression of plaque deposition with advancing AD starting in the neocortex (phase 0-2) and progressing into the midbrain (phase 3) and hindbrain (phase 5). By phase 4, neocortical neuritic plaques are sufficiently abundant to be detectable by PET imaging. Panel a. The abundance of both diffuse and neuritic plaques increase with advancing amyloid phase. The plots represent mean neocortical plaque frequencies (0 = none, 1 = sparse, 2 = moderate and 3 = frequent) per amyloid phase and plaque frequency is determined by the CERAD single point estimate for each subject (N = 106). Panel b . Neocortical plaque frequencies as determined by mCERADSOT using multiple measures per region (N = 106). Note three outliers (solid black circles) in phase 4/5 with mCERADSOT below 1.5 meaning that these cases were considered normal by mCERADSOT but abnormal by amyloid phase. Two of these cases (A and C) were false positives by majority, while B was true negative by majority, but only by a 3:2 reader split. Panel c . The probability of positive global PET assessment increases with amyloid phase (N = 5 for each subject, N = 35, 50, 25, 70, 120 and 230 for phases 0–5 respectively). For all panels, boxes represent mean +/- 1 standard error and whiskers represent 95% confidence interval. Open circles represent outlier values and asterisks represent extreme values (see Materials and methods for details)

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