Fig. 1
From: Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection
The GE067-026 cohort contained a broad and continuous spectrum of neocortical neuritic plaque burden. Panel a. Subjects ranked by the maximal mCERADSOT score for CERAD regions demonstrating a number of cases where dichotomy was based on a burden close to the threshold of 1.5. (cases were determined to be abnormal if any regional score was greater than 1.5, i.e. if the upper ‘whiskers’ in the plot are over 1.5). Most disparities between pathology and PET dichotomy as abnormal or normal occur in cases where the neuritic plaque mCERADSOT score is close to the threshold. Downward arrowheads indicate abnormal cases that were assessed as normal by PET (false negatives) and asterisks indicate normal cases assessed as abnormal (false positives). Panel b. The spread of cases categorised by CERAD neuritic plaque frequency