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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity

Fig. 1

Aβ triggers an aberrant homeostatic response during neuronal activity deprivation. a1 Treatment paradigm. Neurons were treated with Aβ alone, TTX alone, or TTX and Aβ together (TTX/Aβ) for 24 h prior to mEPSC recordings. a2 Sample mEPSC traces showing Aβ-mediated HSP. a3 Quantification of mEPSC amplitudes (control = 12.9 ± 0.75, n = 9; Aβ = 10.9 ± 0.79, n = 9; TTX = 17.7 ± 0.67, n = 7; TTX/Aβ = 20.6 ± 0.82, n = 8. b, c Cumulative probability plots showing no change in inter-event interval (b) and a typical multiplicative scaling effect on mEPSC amplitude (c). Mann–Whitney U test. *p < 0.05, **p < 0.01, ***p < 0.001

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