Fig. 1From: β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticityAβ triggers an aberrant homeostatic response during neuronal activity deprivation. a1 Treatment paradigm. Neurons were treated with Aβ alone, TTX alone, or TTX and Aβ together (TTX/Aβ) for 24 h prior to mEPSC recordings. a2 Sample mEPSC traces showing Aβ-mediated HSP. a3 Quantification of mEPSC amplitudes (control = 12.9 ± 0.75, n = 9; Aβ = 10.9 ± 0.79, n = 9; TTX = 17.7 ± 0.67, n = 7; TTX/Aβ = 20.6 ± 0.82, n = 8. b, c Cumulative probability plots showing no change in inter-event interval (b) and a typical multiplicative scaling effect on mEPSC amplitude (c). Mann–Whitney U test. *p < 0.05, **p < 0.01, ***p < 0.001Back to article page