Fig. 6

CD15 expression is significantly enriched in recurrent pituitary adenomas. a Representative pre- and post-operative MRI of a primary and matched-recurrent pituitary adenoma showing limited residual tumor following primary tumor resection and enhanced growth at recurrence. b NanoString and (c) in silico gene expression data showing enrichment of stemness genes in recurrent adenomas as compared to primary tumors. CD15 expression characterizes pituitary adenoma recurrence based on (b) NanoString and (d) in silico gene expression profiling. Representative CD15 stain in (e) primary (×50) and (f) matched-recurrent (×50) pituitary adenoma identifying a substantial increase in CD15 expression at tumor recurrence