Fig. 5
From: The identification of human pituitary adenoma-initiating cells
CD15+ pituitary adenoma-initiating cells promote multi-lineage specification in vivo. Representative immunostains from PA22 CD15+ xenografts (left panel) and corresponding PA22 patient tissue (right panel). Diffuse positivity for (a) synaptophysin and (b) CD56 indicating neuroendocrine origin of tumor cells. c Desmin and (d) myogenin reactivity seen exclusively in xenografts suggesting multi-lineage specification for CD15+ PAICs. e Cytokeratin (AE1/AE3) reactivity present in patient tissue but absent in xenograft indicating possible clonal divergence in xenograft. All images are at magnification ×200. Scale bare = 100μm