Fig. 1
From: An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability
Case presentation. a Timeline of the evolution of clinical symptoms. b and c Demonstration of absent supranuclear gaze palsy (SNGP) despite clear postural instability (PI) in the 9th year after symptom onset. d MRI showing predominant midbrain atrophy in the 13th year after symptom onset. e Representative histopathological section (pallidum) showing the typical histopathological hallmarks of PSP), i.e. tufted astrocytes (TA), coiled bodies (CB), neurofibrillary tangles (NFT) and neuropil threads (NT) (Gallyas silver stain). f Histopathological section (globus pallidus) with loss of neurons, intracytoplasmic inclusions and gliosis (Hematoxilin-Eosin staining). g Tufted astrocytes in striatum (globus pallidus) as the neuropathological hallmark of PSP (Gallyas silver stain)