Fig. 7

The anterior thalamic nucleus demonstrates p-MAPT neuropathology predominantly in NIA/AA stage B3. a. Images (original magnification 200x) from sections of the anterior thalamic nucleus from representative cases with NIA/AA stages B0-1, B2 or B3 neuropathology are shown. Cases with B0-1 neurofibrillary degeneration demonstrated no significant process or neuronal staining in the anterior thalamic nucleus (upper panel). Cases with B2 neurofibrillary degeneration (middle panel) demonstrated only very rare AT8-ir processes and neurons. Cases with B3 neurofibrillary degeneration (bottom panel) demonstrated frequent AT8-ir processes and neurons. b. Cases with B3 neurofibrillary degeneration, but not B2 neurofibrillary degeneration, demonstrated increased AT8-ir processes (upper graph; p < 0.001, ANOVA; Bonferroni post-hoc test comparisons as indicated) and neurons (lower graph; p < 0.001, ANOVA; Bonferroni post-hoc test comparisons as indicated) compared to cases with B0-1 neurofibrillary degeneration. c. Correlation analysis revealed a significant correlation between Braak stages of neurofibrillary degeneration and both AT8-ir processes (n = 37, R = 0.689, p < 0.001) and AT8-ir neurons (n = 37, R = 0.767, p < 0.001) in the anterior thalamic nucleus