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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Fig. 4

The nucleus accumbens demonstrates p-MAPT neuropathology in NIA/AA stages B2 and B3. a. Images (original magnification 200x) from sections of the nucleus accumbens from representative cases with NIA/AA stages B0-1, B2 or B3 neuropathology are shown. Cases with B0-1 neurofibrillary degeneration demonstrated rare AT8-ir process but no significant neuronal staining in the nucleus accumbens (upper panel). Cases with B2 and B3 neurofibrillary degeneration (middle and lower panels, respectively) demonstrated AT8-ir processes and neurons. b. Cases with B3 neurofibrillary degeneration demonstrated increased AT8-ir processes (upper graph; p < 0.001, ANOVA; Bonferroni post-hoc test comparisons as indicated) and neurons (lower graph; p < 0.001, ANOVA; Bonferroni post-hoc test comparisons as indicated) compared to cases with B0-1 neurofibrillary degeneration. Cases with B2 neurofibrillary degeneration demonstrated trends towards increased AT8-ir processes and neurons compared to cases with B0-1 neurofibrillary degeneration (Bonferroni post-hoc test comparisons as indicated in graph panels). c. Correlation analysis revealed a significant correlation between Braak stages of neurofibrillary degeneration and both AT8-ir processes (n = 37, R = 0.656, p < 0.001) and AT8-ir neurons (n = 37, R = 0.532, p = 0.002) in the nucleus accumbens

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