Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Fig. 3

The septum demonstrates p-MAPT neuropathology in NIA/AA stages B2 and B3. a. Images (original magnification 100x) from sections of the septum from representative cases with NIA/AA stages B0-1, B2 or B3 neuropathology are shown. Cases with B0-1 neurofibrillary degeneration demonstrated no significant process or neuronal staining in the septum (upper panel). Cases with B2 and B3 neurofibrillary degeneration (middle and lower panels, respectively) demonstrated AT8-ir processes and neurons. b. Cases with B2 and B3 neurofibrillary degeneration demonstrated increased AT8-ir processes (upper graph; p < 0.001, ANOVA) and neurons (lower graph; p < 0.001, ANOVA) compared to cases with B0-1 neurofibrillary degeneration (Bonferroni post-hoc test comparisons as indicated in the figure panel). c. Correlation analysis revealed a significant correlation between Braak stages of neurofibrillary degeneration and both AT8-ir processes (n = 37, R = 0.599, p < 0.001) and AT8-ir neurons (n = 37, R = 0.456, p = 0.015) in the septum

Back to article page