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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

Fig. 2

The body of the fornix demonstrates p-MAPT immunoreactive axons in NIA/AA stages B2 and B3. a. Images (original magnifications 400x) from coronal sections of the body of the fornix from representative cases with NIA/AA stages B0-1, B2 or B3 neurofibrillary degeneration are shown. Cases with B0-1 neurofibrillary degeneration demonstrated no punctate axonal staining in the fornix (upper left panel). Cases with B2 and B3 neurofibrillary degeneration (middle-left and lower-left panels, respectively) demonstrated punctate axonal AT8 staining in the fornix (arrowheads). b. Representative macroscopic image (original magnification 10x) of and H&E stained section of the body of the fornix. c. Cases with B2 and B3 neurofibrillary degeneration demonstrated increased AT8-immunoreactive (AT8-ir) axons compared to cases with B0-1 neurofibrillary degeneration (p <0.001, ANOVA; Bonferroni post-hoc test comparisons as indicated in the figure panel). d. Correlation analysis revealed a significant correlation between Braak stages of neurofibrillary degeneration and AT8-ir axons in the fornix (n = 39, R = 0.622, p < 0.001)

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