Fig. 6
From: Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
Expression of Nrf2-regulated genes is increased in toxic AVM muscle. a. mRNA levels of the Nrf2-regulated genes Nqo1, Hmox1, Gsr, G6pd, and Gclc (but not Gclm) were significantly higher in the toxic AVM group (solid circles) than in the normal control group (empty circles). Each study subject is represented with a symbol; solid lines indicate group medians. Data were not normally distributed and were thus analyzed with the Mann-Whitney non-parametric test; *, p < 0.05; **, p < 0.01; ***, p < 0.001. b. In subjects from the toxic AVM group, Nqo1 and Hmox1 protein levels were increased relative to subjects from either normal or drug-treated control groups. Each lane contains a sample from a different study subject, with subject ID numbers indicated on top. GAPDH was used as a loading control