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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies

Fig. 4

Quantification of fibers with Keap1-positive sarcoplasmic inclusions differentiates IBM from PM specimens. a. The percentage of fibers with the Keap1-positive sarcoplasmic puncta and/or inclusions was significantly higher in the IBM group (solid squares) than in the PM group (open squares). Each study subject is represented with a symbol; solid lines indicate group medians. Dashed lines indicate the cutoff values for 100 % sensitivity (6.25 %) and 100 % specificity (14.00 %), as determined by ROC analysis. (***, p < 0.001; unpaired t-test with Welch’s correction for unequal variances). b. ROC analysis indicates that quantification of fibers with the Keap1-positive sarcoplasmic aggregates successfully differentiates IBM from PM cases (area under the curve = 0.96; p < 0.0001)

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