Fig. 3From: Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathiesKeap1 immunohistochemistry labels large sarcoplasmic inclusions in IBM muscle. a-b. In a representative PM specimen (subject #38), there is an increase in diffuse sarcoplasmic Keap1 staining in necrotic fibers (arrowheads), but no Keap1-positive sarcoplasmic puncta or inclusions are detected. c-d. In a representative IBM sample (subject #52), the Keap1-positive sarcoplasmic inclusions are observed in multiple fibers (arrows). Scale bars, 50 μMBack to article page