Fig. 2
From: Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
Quantification of fibers with Keap1-positive coarse sarcoplasmic puncta differentiates toxic AVM from control muscle specimens. a. The percentage of fibers with Keap1-positive coarse puncta was significantly higher in the toxic AVM group (solid circles) than in the normal control group (open circles) or the drug-treated control group (semi-solid circles). Each study subject is represented with a symbol; solid lines indicate group medians. The dashed line indicates a cutoff value with a 100Â % sensitivity and 100Â % specificity (6.25Â %), as determined by ROC analysis. (****, p < 0.0001; *, p < 0.05; Kruskal-Wallis ANOVA on ranks). b. ROC analysis indicates that among colchicine- or HCQ-treated subjects, quantification of muscle fibers with Keap1-positive coarse sarcoplasmic puncta successfully differentiates AVM from control cases (area under the curve = 1.00; p < 0.0001)