Fig. 1

Immunohistochemical detection of phosphorylated tau in tissue of human prion disease patients. a Occurrence of hyperphosphorylated tau (AT8 antibody) in the frontal cortex of a vCJD case (case #20). b Hyperphosphorylated tau is associated with “grape-like” clusters of spongiosis in the frontal cortex of a vCJD case (case #20). c Occurrence of hyperphosphorylated tau in the frontal cortex of a sCJD case (case #46). d Hyperphosphorylated tau in the frontal cortex of a sCJD case (case #46) showing a neuronal/perineuronal localization. e Occurrence of hyperphosphorylated tau positive neuropil threads and tangle-like changes in a sCJD case (case #26). f Immunohistochemical detection of hyperphosphorylated tau in the frontal cortex of an AD case (case #59) showing staining of neuritic plaques, neuropil threads and neurofibrillary tangle-like structures. a-f Brown staining with DAB, blue staining of the nucleus with haematoxylin. Bar a, c, e ,f 100 μm; b, d 20 μm