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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain

Fig. 6

In vitro aggregation of Aβ peptides studied by ThT fluorescence and infrared spectroscopy. a The time course of aggregation of Aβ42, of Aβ24, and of the equimolar mixture of the two peptides incubated at 37 °C in PBS was monitored by ThT fluorescence with excitation and emission wavelengths at 450 nm and 485 nm, respectively. b ThT fluorescence emission spectra (excitation at 450 nm) of samples as in a) reported for selected incubation times. c Fluorescence emission spectra with excitation at 270 nm of Aβ42 and of Aβ24 incubated at 37 °C in PBS for 96 h. d ATR-FTIR spectra of Aβ42, of Aβ24, and H-Aβ42/H-Aβ24 mix incubated at 37 °C in PBS for different times, as indicated. Spectra are reported after Fourier self deconvolution (see Materials and Methods)

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