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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity

Fig. 3

a Co-expression of neprilysin2 suppresses the toxicity of AβpE3-42 expressing flies. Top, light microscopy images and bottom, transverse sections. From left to right, GMR-GAL4/UAS-EGFP;UAS-AβQ3-42/+ and GMR-GAL4/UAS-EGFP;UAS-AβQ3-42/NEP2 (EP(3)3549). Flies were grown at 28 °C. b Neprilysin2 significantly reduces AβpE3-42 protein levels, *P < 0.001.pE3-42 levels were quantified by ELISA. Data are presented as means ± SEM and were analysed by Student t test

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