Fig. 6

The connections of motor neuron-related area. The common lesion of the ALS patients who progressed to Stage V is emphasized. All the common lesions related to the motor neurons and pyramidal tract. Shaded areas: lesions that showed moderate or severe degeneration in all the patients regardless of the time for progression to Stage V to death or type of accumulated protein. Stippled areas: lesions that showed a different degree of degeneration depending on the time from progression to Stage V to death