Fig. 5

Immunohistochemical features of cerebral lesions. a–c Patient 2 with phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI) in the hippocampal dentate granule neurons (c) had occasional NCI in the frontal (a) and temporal (b) cortex. d–f Patient 6 without pTDP-43-ir NCI in the hippocampal dentate granule neurons (f) had rare NCIs in the frontal cortex (d) and no NCIs in the temporal cortex (e). g–i Patient 7 with occasional fused in sarcoma (FUS)-ir NCI in the frontal cortex (g) and rare NCI in the temporal cortex (h) had no NCI in the hippocampal dentate granule neurons. j–l Patient 8 without FUS-ir NCI in the frontal (j) and temporal cortex (k) had rare NCI in the hippocampal dentate granule neurons (l). Bar = 50 μm