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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

Fig. 5

Immunohistochemical features of cerebral lesions. ac Patient 2 with phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI) in the hippocampal dentate granule neurons (c) had occasional NCI in the frontal (a) and temporal (b) cortex. df Patient 6 without pTDP-43-ir NCI in the hippocampal dentate granule neurons (f) had rare NCIs in the frontal cortex (d) and no NCIs in the temporal cortex (e). gi Patient 7 with occasional fused in sarcoma (FUS)-ir NCI in the frontal cortex (g) and rare NCI in the temporal cortex (h) had no NCI in the hippocampal dentate granule neurons. jl Patient 8 without FUS-ir NCI in the frontal (j) and temporal cortex (k) had rare NCI in the hippocampal dentate granule neurons (l). Bar = 50 μm

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