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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

Fig. 3

Lesions of the nonmotor system. ac Substantia nigra showing severe neuronal loss with gliosis. df Globus pallidus, gi putamen. Only patient 7 showed more severe degeneration in the putamen (h) than in the globus pallidus (e). Other patients showed more severe degeneration in the globus pallidus (d, f) than in the putamen (g, i). a-d, h neuronal loss and gliosis were severe (+++). e-g neuronal loss and gliosis were mild (++). i neuronal loss and gliosis were slight (+). a, d, g Patient 2 with phosphorylated TAR DNA-binding protein 43-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI). b, e, h Patient 7 with fused in sarcoma-ir NCI. c, f, i Patient 10 with copper/zinc superoxide dismutase-ir NCI, (Bar = 50 μm, hematoxylin and eosin staining)

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