Fig. 3

Dictyostatin doses of 0.3 mg/kg biweekly or 0.1 mg/kg weekly did not exacerbate body weight loss in 6-month old PS19 mice. Male 6-month old PS19 mice received either biweekly ip injections of 0.3 mg/kg dictyostatin, weekly injections of 0.1 mg/kg dictyostatin, or weekly injections of vehicle (n = 11/treatment). In addition, wild-type male 6-month old B6 mice received weekly injections of vehicle. Body weights were recorded weekly. A total of 6 mice in the 0.3 mg/kg dictyostatin group and 3 mice in the 0.1 mg/kg dictyostatin group died before study completion. Error bars represent SEM