Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice

Fig. 3

Differences emerge between young and aged rNLS8 mice as the ALS-like disease progresses. a After 6 weeks of transgene expression, aged mice show differences in both TA and soleus innervation compared to young mice, p = 0.04 and p = 8.3E-4, n = 3–4. b Aged mice also have fewer lumbar MNs than young rNLS8 mice at 6 weeks off Dox. Data are mean ± SD (n = 3–4 for both young and aged mice; p = 1.2E-04), ∗ p < 0.05, ***p < 0.001. c Aging significantly accelerates time to death after transgene induction in rNLS8 mice. Median time to death is 6.5 weeks for aged mice vs. 10.3 weeks for young mice. (n = 10 for aged mice, n = 29 for young mice, Log rank test statistic = 18.7, p < 0.001)

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us