Fig. 8

Impact of recurrent stroke on the acute, sub-acute and chronic inflammatory response to stroke in C57BL/6 and BALB/c mice. Graphs show a comparison of the levels of 25 cytokines and chemokines in acute infarcts (a and b), sub-acute infarcts (c and d), and infarcts at the stage of liquefactive necrosis (e and f) dissected from a first or second stroke. In mice that underwent two stroke procedures, each stroke was separated by 3 weeks. Only the infarct at the site of the second stroke was compared to the infarct from mice that had undergone a single stroke procedure. Data are expressed as a fold-change relative to values from mice that underwent a single sham surgery. Blue text denotes where there is a significant difference in the overall cytokine and chemokine profile between the first and second stroke by two-way ANOVA. Cytokines and chemokines that are significantly different between the first and second stroke, corrected for multiple comparisons, are denoted by an asterisk