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Table 4 Statistical analysis outputs on Western blot assays of wt and Npc1 nmf164 littermates either sham- or CD-treated

From: Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis

 

Genotypea

Treatmentb

Genotype x treatment

GFAP

50 kDa

F (1,12) = 29.35, p = 0.0001

F (1,12) = 52.17, p < 0.0001

F (1,12) = 0.70, p = 0.42

48 kDa

F (1,12) = 199.21, p < 0.0001

F (1,12) = 152.93, p < 0.0001

F (1,12) = 8.78, p = 0.01

GLAST

F (1,12) = 22.77, p = 0.0005

F (1,12) = 95.83, p < 0.0001

F (1,12) = 9.63, p = 0.01

Glutamine Synthetase

F (1,12) = 12.85, p = 0.004

F (1,12) = 12.51, p = 0.004

F (1,12) = 11.48, p = 0.005

VGluT2

F (1,12) = 0.83, p = 0.38

F (1,12) = 5.47, p = 0.04

F (1,12) = 26.21, p = 0.0003

GAD65

F (1,12) = 13.53, p = 0.003

F (1,12) = 22.02, p = 0.0005

F (1,12) = 21.89, p = 0.0005

MBP

21.5 kDa

F (1,12) = 0.14, p = 0.71

F (1,12) = 3.37, p = 0.09

F (1,12) = 74.51, p < 0.0001

18.5 kDa

F (1,12) = 0.04, p = 0.84

F (1,12) = 5.60, p = 0.04

F (1,12) = 24.13, p = 0.0004

17.2 kDa

F (1,12) = 1.55, p = 0.24

F (1,12) = 47.36, p < 0.0001

F (1,12) = 92.86, p < 0.0001

  1. adifferences were analyzed by two-way ANOVAs
  2. b wt and Npc1 nmf164 littermates received subcutaneous injections of plain PBS or CD, according to the schedule of Fig. 1
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Acta Neuropathologica Communications

ISSN: 2051-5960

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