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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis

Fig. 2

Npc1 nmf164 pups show a delay in the acquisition of complex motor skills requiring fine motor coordination and balance. a Line graph indicates body weight values of experimental group mice of increasing age. Histograms indicate the day of onset of physical development landmarks. b-d Histograms indicate the fraction of: pups engaged in pivoting, crawling or quadrupedal locomotion (b); pups floating, swimming in circles or in a straight line (c); pups paddling with only forelimbs, four limbs or only hindlimbs (d) in the PN3-PN15 time interval. e-f Histograms indicate the day of onset of sensorimotor reflexes (e) and complex motor skills (f). Note that Npc1-deficiency delays the acquisition of complex motor behaviors requiring fine motor coordination and balance, whereas it does not influence physical and sensorimotor development. a, e, f Data are expressed as mean ± SEM. b-d Data are expressed as percentages of animals displaying the behavior. * p ≤ 0.01

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