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Table 2 Severity and distribution of TDP-43-immunoreactive deposition

From: Neuropathology of supercentenarians - four autopsy case studies

Areas

Case 1

Case 2

Case 3

Case 4

 

NCI

Neurites

NNI

GCI

NCI

Neurites

NNI

GCI

NCI

Neurites

NNI

GCI

NCI

Neurites

NNI

GCI

Basal ganglia

Basal forebrain; +++

Basal forebrain; +

-

+

-

-

-

-

-

-

-

-

-

-

-

-

Temporal lobe

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Uncus

-

++

-

+

-

-

-

-

-

+

-

-

-

-

-

+/−

Hippocampus-PHG

CA1; +++ Subiculum; +++ Dentate fascia; +/−

CA1; +++ Subiculum; +++

+

+

CA1; ++ subiculum++ Dentate fascia;+/−

CA1; ++ subiculum++

-

+

-

-

-

-

-

-

-

-

Motor cortex

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Midbrain

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Medulla

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Spinal cord

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

  1. Abbreviations: GCI glial cytoplasmic inclusions, NCI neuronal cytoplasmic inclusion, NNI neuronal nuclear inclusion, PHG parahippocampal gyrus
  2. -: none
  3. +: mild
  4. ++: moderate
  5. +++: severe