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Table 2 Severity and distribution of TDP-43-immunoreactive deposition

From: Neuropathology of supercentenarians - four autopsy case studies

Areas Case 1 Case 2 Case 3 Case 4
  NCI Neurites NNI GCI NCI Neurites NNI GCI NCI Neurites NNI GCI NCI Neurites NNI GCI
Basal ganglia Basal forebrain; +++ Basal forebrain; + - + - - - - - - - - - - - -
Temporal lobe - - - - - - - - - - - - - - - -
Uncus - ++ - + - - - - - + - - - - - +/−
Hippocampus-PHG CA1; +++ Subiculum; +++ Dentate fascia; +/− CA1; +++ Subiculum; +++ + + CA1; ++ subiculum++ Dentate fascia;+/− CA1; ++ subiculum++ - + - - - - - - - -
Motor cortex - - - - - - - - - - - - - - - -
Midbrain - - - - - - - - - - - - - - - -
Medulla - - - - - - - - - - - - - - - -
Spinal cord - - - - - - - - - - - - - - - -
  1. Abbreviations: GCI glial cytoplasmic inclusions, NCI neuronal cytoplasmic inclusion, NNI neuronal nuclear inclusion, PHG parahippocampal gyrus
  2. -: none
  3. +: mild
  4. ++: moderate
  5. +++: severe
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