Table 1 Study participant characteristics
From: Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression
Cohort | Variable | AD | Control | P-value |
|---|---|---|---|---|
Discovery (UCSF) | N | 31 | 245 | |
Age at Onset / First Visit | 77.8 ± 4.5 | 68.5 ± 8.5 | p < 0.001 | |
Sex (M / F) | 16 / 15 | 99 / 146 | 0.18 | |
Edu (Years, Mean ± SD) | 17.0 ± 3.7 | 17.3 ± 2.1 | 0.45 | |
CDR (Mean ± SD) | 0.8 ± 0.3 | 0.0 ± 0.1 | p < 0.001 | |
MMSE (Mean ± SD) | 22.2 ± 5.3 | 29.4 ± 0.8 | p < 0.001 | |
APOE ε4 dose (0 / 1 / 2) | 9 / 17 / 5 | 190 / 48 / 4 | p < 0.001 | |
# Pathological Confirmed AD | 12 | |||
Replication (ADSP) | N | 2927 | 2633 | |
Age at Onset / First Visit | 75.3 ± 8.4 | 85.5 ± 5.1 | p < 0.001 | |
Sex (M / F) | 1299 / 1628 | 1185 / 1448 | 0.639334 | |
Edu (Years, Mean ± SD) | NA | NA | NA | |
CDR (Mean ± SD) | NA | NA | NA | |
MMSE (Mean ± SD) | NA | NA | NA | |
APOE ε4 dose (0 / 1 / 2) | 1660 / 1184 / 83 | 2239 / 386 / 8 | p < 0.001 | |
# Pathological Confirmed AD | 1057 |