Fig. 2
Behavioural characterization of αSYNtg/tg transgenic mice in the context of telomere shortening. Behavioral experiments were performed before the occurrence of a motoric phenotype. All mice were tested at an age of 72 weeks (n = 7–10). a-d Beamwalk: Mice were trained for three consecutive days to walk over a wooden beam. The test was performed with different beam diameters and shapes (square or round). Graphs show the latency to walk over a beam with a square diameter of a 28 mm (αSYNtg/tg G3Terc-/- mice vs. αSYNtg/tg; p = 0.0095), b 12 mm (αSYNtg/tgG3Terc-/- mice vs. αSYNtg/tg; p = 0.0023) or a round beam with a diameter of c 28 mm (αSYNtg/tg G3Terc-/- mice vs. αSYNtg/tg; p = 0.0095), and d 17 mm (αSYNtg/tg G3Terc-/- mice vs. αSYNtg/tg; p = 0.003). αSYNtg/tg G3Terc-/- mice showed a reduced latency to cross the different beams. e Number of footslips. αSYNtg/tg G3Terc-/- mice show a significant increase in the number of footslips in comparison to αSYNtg/tg mice (p < 0.0001; 2-way Anova)