Fig. 4
From: Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
Aβ levels in fractionated brain tissue of young and aged degus. Levels of Aβ40 and Aβ42 were measured in fractionated cortical (black) and hippocampal (grey) tissue of young (a, c) and aged (b, d) degus using immunoassays. a, b In both groups, Aβ40 was rarely present in soluble (TBS) and membrane-bound (TX-100) forms. The highest amounts were protein-bound (SDS) and smaller proportions were insoluble (formic acid; FA). Overall, young and aged animals demonstrated very similar levels Aβ40. c, d Young and aged degus showed low levels of Aβ42 in soluble (TBS) and membrane-bound (TX-100) fractions and higher levels in protein-bound (SDS) and insoluble (FA) fractions in both, cortex and hippocampus. Aβ42 levels were likewise not crucially changed in aged animals. Data is presented as mean ± SEM (young: 3, 24 months; aged: 56, 56, 65, 65 months)