Fig. 1

Comparison of human and rodent Aβ sequences. Part a shows a simplified phylogenetic tree of rodents. In b, human and rodent sequences of Aβ₄₂ are compared. The Aβ sequence of guinea pigs (green) equals the human sequence. Chinchillas, degus and naked mole rats (NMRs) share the same sequence (yellow) with one variation at position 13 as compared to humans. The lesser Egyptian jerboa has an additional difference at position 10 (orange). A larger group of rodents, including mice and rats, show 3 sequential differences at 5, 10 and 13 (red). This sequence is often erroneously referred to as “rodent Aβ”, as it is the most frequent sequence in rodents. The uniformity of human and degu tau at the analysed phosphorylation sites is shown in c