Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia

Table 1 DYT1 dystonia neuropathology studies

References	Subjects	Inclusions	Key antibodies	Subcellular TorsinA immunoreactivity
Walker et al. 2002 [11]	1 DYT1 Dystonia subject	No	Anti-torsinA (rabbit polyclonal: AA residues 323–332)	Nucleus, cytoplasm, and dendrites in both DYT1 dystonia and control groups
Walker et al. 2002 [11]	4 control subjects	No	Anti-torsinA (rabbit polyclonal: AA residues 323–332)
Rostasy et al. 2003 [12]	5 DYT1 Dystonia subjects	No	Anti-torsinA (rabbit polyclonal TAB1: AA residues 299–312; mouse monoclonal D-MG10: AA residues 208–249)	Cytoplasm, dendrites, and axons in both DYT1 dystonia and control groups
Rostasy et al. 2003 [12]	20 control subjects	No
McNaught et al. 2004 [9]	4 DYT1 Dystonia subjects	Yes: midbrain, pons	Anti-torsinA (rabbit polyclonal; AA residues 323–332), Anti-ubiquitin, Anti-UPC, Anti-ChAT	Perinuclear and intranuclear inclusions in DYT1 dystonia group only
McNaught et al. 2004 [9]	4 control subjects	No
Paudel et al. 2014 [10]	7 DYT1 Dystonia subjects	No	Anti-ubiquitin, Anti-p62	N/A

AA amino acid, ChAT choline acetyl transferase, UPC ubiquitin-protein conjugate

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